Medical Providers

Are you looking for answers for families with unexplained pregnancy loss?

Stanford, UCSF, and OHSU have teamed up to perform an NIH-sponsored multicenter study to understand genomic predictors of unexplained recurrent pregnancy loss. Eligible subjects must have had two or more losses at any gestation and least one pregnancy of the pregnancy losses was chromosomally normal. Our goal is to identify novel genetic mechanisms for euploid pregnancy loss. Patients are eligible if any pregnancy tissue is available for analysis. Often testing laboratories and pathology departments store tissue for a period of time after testing and this tissue can be ordered and used for our study. Our team will investigate and coordinate all aspects of the study. 

Study activities include collecting DNA from patients and miscarriage tissues some self online questionnaires about medical and pregnancy history, whole genome sequencing of parents and pregnancy tissue, and brief online surveys. Parents and pregnancy tissue (when available) will be sequenced and analyzed for known and novel pregnancy loss genes. Patients may opt to receive results of pathogenic variants and genetic counseling will be provided. Patients planning future pregnancy may be eligible for financial compensation if they are willing to provide additional blood samples before and during pregnancy. Any of our investigators would be happy to talk with you or your staff to provide general information about our experience with miscarriage testing or recurrent pregnancy loss or discuss any aspect of this study.

For providers serving patients who have experienced a miscarriage, the first step for patients is to request additional testing in order to determine if the pregnancy loss was due to aneuploidy. 

Feel free to refer patients to this website and display the flyers below in your clinic or practices.

 

Frequently Asked Questions (FAQ)

Is my patient eligible to enroll?

Women are eligible to participate in this study if:

  • They are older than 15 y.o
  • They experience a miscarriage of unknown cause
  • They are willing to participate in this study
How do I refer a patient to this study?

You can refer your patients to this study website and encourage them to participate by CLICKING HERE

You or your patients can also contact us by email at [email protected]

Do I need IRB approval to refer a patient?

No – The IRB has given permission for you to refer a patient and send her contact information as long as she has consented to sharing her contact information with us.

Do I need a document that my patient has given permission to pass her name to us?

No. However, if you would like to, you may document this in the medical record using this TEMPLATE FORM

What will happen if I refer a patient directly?

After you refer a patient, the study team will reach out to provide information and enroll her into the study. You will not have to collect any additional information from your patient who enrolled in this study. 

Will I be required to send any information about my patient to UCSF?

We will ask the patient to sign an authorization to release medical records. We will contact your office to assist us in obtaining relevant medical record information.

How will the study data be shared?

We will present and publish our findings as our analyses. We hope to create a resource for advancing scientific knowledge, women’s health, and infant development broadly. This is a collaborative effort. We welcome our current and prospective collaborators to contact us for more information at [email protected].